Job Description

A drug discovery and development company in San Diego is seeking a Senior Director, Medicinal Chemistry to join their dynamic and collaborative team dedicated to translating cutting-edge science into life-changing treatments for patients with severe unmet medical needs. Scope and Responsibilities: We are seeking a Senior Director, Medicinal Chemistry to lead our small molecule discovery efforts. This is a pivotal role for a scientific leader who will drive medicinal chemistry strategy, oversee external collaborations, and advance programs from target identification through clinical development. The successful candidate will play a key role in shaping our chemistry function, optimizing resources, and mentoring the next generation of drug discovery scientists. Lead and drive medicinal chemistry programs from hit discovery through Phase 1, contributing to our expanding pipeline. Develop and execute chemistry strategies that balance innovation, efficiency, and risk mitigation. Oversee internal and external teams, managing collaborations with CROs and global FTEs while expanding our chemistry capabilities. Act as a scientific thought leader, integrating medicinal chemistry with biology, pharmacology, and computational chemistry to optimize small molecules. Provide mentorship and leadership, building and scaling a high-performing team of chemists to support our growth. Guide structure-activity relationship (SAR) optimization, integrating ADME, PK, and safety data to drive compound progression. Support strategic planning for IND-enabling studies and contribute to clinical candidate nomination. Collaborate cross-functionally with discovery biology, computational chemistry, and translational teams to accelerate drug development. Key Selection Criteria: PhD in Chemistry with 10+ years of medicinal chemistry experience in biotech or pharma. Proven track record of leading drug discovery programs from early-stage discovery through clinical candidate nomination. Strong expertise in synthetic organic chemistry, medicinal chemistry, and structure-based drug design. Experience managing external partnerships and global chemistry teams. Excellent leadership, communication, and team-building skills, with a passion for mentoring junior scientists. Ability to work in a fast-paced, collaborative biotech environment and drive innovation. Why join? Exciting Growth – We are scaling rapidly, with upcoming IND filings and plans for a future public offering. Career Development – This role offers opportunities for professional growth as the pipeline and team expand. It is a dynamic work environment where unique strengths of employees at all levels are cultivated. Cutting-Edge Science – Work at the forefront of genetics-driven drug discovery, translating groundbreaking insights into transformative medicines. Collaborative Culture – Join a team that values teamwork, inclusion, and scientific excellence. Including planning regular company events and opportunities to participate in team-building gatherings and activities designed to foster open communication and engagement. Competitive Compensation & Benefits: ~ Medical, dental and vision insurance ~ Health Savings Account with a rich employer contribution ~ Mental health and wellness benefits ~401k plan participation plus complimentary financial planning services ~ Equity Incentive Plan participation (stock options) ~ Life/AD&D Insurance ~ Short-term and long-term disability insurance ~ Weeklong winter holiday shutdown ~ Generous paid time off and holiday policies ~ Parental, caregiving, and various leave programs

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