Research Scientist/Senior Research Scientist, Biologics/Immuno-Oncology Job at Calibr, San Diego, CA

d0xZRy9kdDQ4NGNzSkR1Y0ZUV0xMb01U
  • Calibr
  • San Diego, CA

Job Description

Position Title: Research Scientist/Senior Research Scientist, Biologics/Immuno-Oncology

Position Summary

Calibr is seeking a talented Research Scientist in the area of immuno-oncology. This position will work as part of a small team of interdisciplinary scientists to translate innovative cell and protein therapies for the treatment of cancer into first-in-human clinical trials. Specifically, projects will be focused on the development of next generation T cell-recruiting antibodies (bi/multi specific antibodies) and switchable chimeric antigen receptor T (CAR-T).Both platform technologies have the potential to have curative responses for cancer patients.While working within the scope of these projects, this position will also have the unique opportunity to be exposed to a wide range of other projects at Calibr covering infectious and neglected tropical diseases, metabolic disorders, autoimmunity, and others. Calibr's open lab space design and collaborative environment encourages the seamless flow of ideas within and between research groups.This position will receive hands on training in translational research and gain knowledge on how scientific ideas are translated into drugs to help patients in need. The ideal candidate is expected to bring the basic scientific proficiencies listed below at the start. This position offers significant growth opportunity through promotion structures designed to retain exceptional talent within the Calibr family. This position will require training and managing entry level Research Associates, with increased responsibility over time.

Essential Duties and Responsibilities

  • Cell biology including working (isolation, characterization, and assay set up) with primary human and murine immune cells, tumor cell lines used in immuno-oncology research, and primary patient-derived cells.
  • Design and execution of project plans involving immune cell profiling, cell processing from xenograft models, cytotoxicity, proliferation, activation, cell viability, and survival assays with a strong focus on flow cytometry.
  • Gene editing of primary human immune cells using state of the art technologies like CRISPR, TALEN, and other endonucleases while using multiple delivery approaches including protein and mRNA electroporation and multiple viral vector platforms.
  • Generation of reagents for projects including preparation of lentivirus for the transduction of both established cell lines and primary immune cells.
  • Molecular biology experiments including DNA and protein preparation from cells, immunoprecipitation, western blots, etc will be within the scope of work.
  • Preparation of reports and presentation of results at regular team meetings.

Qualifications and Experience

  • A strong background in cell culture and multi-color flow cytometry is essential.
  • Hands-on experience with in vitro assays (co-culture assays) commonly used in immuno-oncology is essential.
  • Experience and knowledge of the immune system is essential. (Experience in T/B/NK/macrophage cell biology, tumor immunology).
  • Experience with protein engineering and antibody design is important.
  • Experience with molecular biology techniques is important.
  • Hands on experience with cellular immunotherapies is preferred.
  • Experience with gene editing , cell transfection and transduction systems is preferred but not required.
  • Experience preparing reagents for in vivo assays and In vivo experience preferred but not required.
  • Experience using Prism, FlowJo, Office, and JMP software is important.
  • Details of established essential functions for this position will be addressed/discussed during the interview process.

Requirements

  • Bachelor's degree in biology, chemical biology, biochemistry, or related field required. PhD is highly preferred.
  • Minimum 2 years' experience in the industry required.
  • Impeccable attention to detail, and excellent ability to perform hands-on experiments, research, design, and organize project designs and maintain detailed documentation.
  • Highly motivated, creative, and devoted to project goals.
  • Able to collaborate proficiently and communicate effectively with colleagues and management teams.
  • Able to contribute in a meaningful way to scientific discourse.

Physical Requirements :

This position works in a laboratory environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

COMPENSATION

The expected hiring range for this position is $90,000.00 to $130,000.00 commensurate with experience.

COMPREHENSIVE BENEFITS INCLUDE

  • Employer Contributed Retirement Plan - Depending on eligibility, employees receive an employer contributed retirement plan (no employee contribution required) and the option to contribute to a 403(b) (which is similar to a 401(k) using your own pre or post-tax dollars)
  • Full Suite of Health and Welfare plans including three medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more
  • Access to Flexible Spending Accounts (Medical/Dependent Care)
  • Competitive vacation and sick leave policies
  • Free, on-site parking

The above statements describe the level of work performed and expected in general terms.The statements are not intended to list all the responsibilities, duties and/or skills required of employees so classified, and the content herein is subject to change due to the business needs of Scripps Research, with or without notice.Furthermore, nothing in this job description shall be interpreted to be in conflict with or to eliminate or modify in any way the employment-at-will status of Scripps Research staff.

EEO Statement:
The Scripps Research Institute is an Equal Opportunity Employer. We promote diversity of thought, culture and background in the fields of science. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status. Underrepresented individuals are encouraged to apply. Calibr

Job Tags

Flexible hours,

Similar Jobs

Maui Pumping

CDL B Driver $5000 hiring bonus Job at Maui Pumping

 ...DONT APPLY Job Title: Septic/Cesspool Pumping Technician NO EXPERIENCE NECESSARY BESIDES HAVING A CDLB OR A LIC Location: Wailuku...  ...of services performed and communicate effectively with the office team. - Adhere to all safety protocols and environmental regulations... 

Jobot

Associate Attorney (General Liability) Job at Jobot

 ...Why join us? Medical Benefits 401k PTO Competitive pay Job Details Responsibilities: As a Permanent Associate Attorney (General Liability), you will be expected to perform a variety of tasks, including but not limited to: 1. Represent clients in all... 

Centurion & Supreme Boats

Finance Manager Job at Centurion & Supreme Boats

 ...is the only affordable premium brand to offer world-class performance, style, simplicity, and strength built to help watersports fanatics maximize their fun on the water at an extreme value.Supremeis continuing to reign supreme as the fastest growing boat brand in the... 

Chula Vista Brewery of Eastlake

Line Cook at Chula Vista Brewery of Eastlake Job at Chula Vista Brewery of Eastlake

 ...Job Description Job Description Chula Vista Brewery in Chula Vista, CA is looking for one line cook to join our 19 person strong team. We are located on 871 Showroom Place #102. Our ideal candidate is a self-starter, motivated, and hard-working. Responsibilities... 

Headway

Launch your private practice! Job at Headway

 ...clients you see through Headway, so that you can set the hours that work for you. Grow your caseload by providing marketing support and...  ...patients in-person or remotely via telehealth while working from home. We accept the following licenses on a state by state basis:...